Publications

2015

  • Hughes-Fulford, M., Chang, T. T., Martinez, E. M., and Li, C. F. (2015) Spaceflight alters expression of microRNA during T-cell activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology PDF

  • Chang, T. T., Spurlock, S. M., Candelario, T. L., Grenon, S. M., and Hughes-Fulford, M. (2015) Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines. FASEB journal : Official Publication of the Federation of American Societies for Experimental Biology. PDF

  • Martinez, E. M., Yoshida, M. C., Candelario, T. L., and Hughes-Fulford, M. (2015) Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 308, R480-488. PDF

2014

  • Chang, T. T., and Hughes-Fulford, M. (2014) Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates. Biomaterials 35, 2162-2171. PDF

2013

  • Grenon, S. M., Owens, C. D., Alley, H., Chong, K., Yen, P. K., Harris, W., Hughes-Fulford, M., and Conte, M. S. (2013) n-3 Polyunsaturated fatty acids supplementation in peripheral artery disease: the OMEGA-PAD trial. Vascular medicine (London, England) 18, 263-274. PDF

  • Grenon, S. M., Jeanne, M., Aguado-Zuniga, J., Conte, M. S.,  and Hughes-Fulford, M. (2013). Effects of Gravitational Mechanical Unloading in Endothelial Cells: Association between Caveolins, Inflammation and Adhesion Molecules. Scientific Reports. 3:1494. PDF

2012

  • Grenon, S. M., Saary, J., Gray, G., Vanderploeg, J. M., and Hughes-Fulford, M. (2012) Can I take a space flight? Considerations for doctors. BMJ 345, e8124-e8124. PDF

  • Chang, T. T., Walther, I., Li, C. F., Boonyaratanakornkit, J., Galleri, G., Meloni, M. A., Pippia, P., Cogoli, A., and Hughes-Fulford, M. (2012) The Rel/NF- B pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity. Journal of Leukocyte Biology 92, 1133-1145. PDF

  • Sonnenfeld, G. (2012) Editorial: Space flight modifies T cell activation--role of microgravity. Journal of Leukocyte Biology 92, 1125-1126. PDF

  • Hughes-Fulford, M., Meissler, J., Aguayo, E. T., Globus, R., Aguado, J., and Candelario, T. (2012) Hyperoxia Inhibits T Cell Activation in Mice. In NASA Human Research Program Investigators' Workshop 2012, Houston, TX. PDF

  • Grenon, S. M., Aguado-Zuniga, J., Hatton, J. P., Owens, C. D., Conte, M. S., and Hughes-Fulford, M. (2012) Effects of fatty acids on endothelial cells: inflammation and monocyte adhesion. Journal of Surgical Research 177, e35-e43. PDF

  • Grenon, S. M., Hughes-Fulford, M., Rapp, J., and Conte, M. S. (2012) Polyunsaturated fatty acids and peripheral artery disease. Vascular Medicine 17, 51-63. PDF

2011

  • Hughes-Fulford, M. (2011) To infinity ... and beyond! Human spaceflight and life science. The FASEB Journal 25, 2858-2864. PDF

  • Campbell, M., Magbanua, M. J. M., Roy, R., Sosa, E. V., Weinberg, V., Federman, S., Mattie, M. D., Hughes-Fulford, M., Simko, J., Shinohara, K., Haqq, C. M., Carroll, P. R., and Chan, J. M. (2011) Gene Expression and Biological Pathways in Tissue of Men with Prostate Cancer in a Randomized Clinical Trial of Lycopene and Fish Oil Supplementation. PLoS ONE 6, e24004. PDF

  • Hughes-Fulford, M., and Li, C. F. (2011) The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization. Journal of Orthopaedic Surgery and Research 6, 8. PDF

  • Chan, J. M., Weinberg, V., Magbanua, M. J., Sosa, E., Simko, J., Shinohara, K., Federman, S., Mattie, M., Hughes-Fulford, M., Haqq, C., and Carroll, P. R. (2011) Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer. Cancer Causes & Control : CCC 22, 141-150. PDF

2010

  • Hughes-Fulford, M., and J. Boonstra (2010). Cell mechanotransduction: cytoskeleton and related signaling pathways. In Cell Mechanochemistry. Biological Systems and Factors Inducing Mechanical Stress, Such as Light, Pressure and Gravity (Monici, M., ed) pp. 75-96, Transworld Research Network. PDF

2009

  • Chang, T. T., and Hughes-Fulford, M. (2009) Monolayer and Spheroid Culture of Human Liver Hepatocellular Carcinoma Cell Line Cells Demonstrate Distinct Global Gene Expression Patterns and Functional Phenotypes. Tissue Engineering Part A 15, 559-567. PDF

2008

  • Hughes-Fulford M., T, C., and CF, L. (2008) Effect of Gravity on Monocyte Differentiation. In 10th ESA Life Sciences Symposium/29th Annual ISGP Meeting/24th Annual ASGSB Meeting/ELGRA Symposium "Life in Space for Life on Earth" Angers, France. PDF

2006

  • Sevigny MB, Li C-F, Alas M and Hughes-Fulford M., Glycosylation regulates turnover of cyclooxygenase-2. 2006 Oct; FEBS Letters 580: 6533-6536. PDF

  • Millie Hughes-Fulford, Karsten Rodenaker, and Uta Jütting, Reduction of anabolic signals and alteration of osteoblast nuclear morphology in microgravity. Cellular Biochemistry 99:435-449 (2006). PDF

  • C-F Li and Hughes-Fulford, M. FGF-2 is an immediate-early gene induced by mechanical stress in osteogenic cells. J Bone Miner Res. 2006 Jun;21(6):946-55. PDF

  • Hughes-Fulford, M. C-F Li, S. Sayyah, and J. Boonyaratanakornkit, Omega-6 fatty acids activate PI3K signaling and induce gene expression in prostate cancer. Cancer Research 2006 , 66 (3) 1427-1433. PDF

2005

  • Boonyaratanakornkit JB, Cogoli A, Li CF, Schopper T, Pippia P, Galleri G, Meloni MA, Hughes-Fulford, M. Key gravity-sensitive signaling pathways drive T cell activation. FASEB J. 2005 Dec;19(14):2020-2. PDF

  • Hughes-Fulford, M., Sugano E, Schopper T, Li C-F, Boonyaratanakornkit J, Cogoli A. Early immune response and regulation of IL-2 receptor subunits, Cellular Signaling Sep;17 (9):1111-24, 2005. PDF

  • Hughes-Fulford, M., Tjandrawinata RR, Li C-F, and Sayyah S. Arachidonic Acid, an Omega-6 Fatty Acid, Induces Cytoplasmic Phospholipase A2 in Prostate Carcinoma Cells, Carcinogenesis, Sep;26(9):1520-6, 2005. PDF

2004

  • Hughes-Fulford, M. Signal transduction and mechanical stress. scienceonline Sci STKE. 2004 Aug 31;2004 (249):RE12. PDF

  • Hughes-Fulford, M. (2004) Lessons learned about spaceflight and cell biology experiments. Journal of Gravitational Physiology : a Journal of the International Society for Gravitational Physiology 11, 105-109. PDF

2003

  • Hatton JP, Pooran M, Li CF, Luzzio C, Hughes-Fulford, M. (2003). A short pulse of mechanical force induces gene expression and growth in MC3T3-E1 osteoblasts via an ERK 1/2 pathway. J Bone Miner Res. 18(1):58-66. PDF

  • Hughes-Fulford, M. (2003). Function of the cytoskeleton in gravisensing during spaceflight. Adv Space Res. 32(8): 1585-93. PDF

2002

  • Hatton JP, Gaubert F, Cazenave JP, Schmitt D.(2002). Microgravity modifies protein kinase C isoform translocation in the human monocytic cell line U937 and human peripheral blood T-cells. J Cell Biochem. 87(1):39-50. PDF

  • Hughes-Fulford, M. The role of signaling pathways in osteoblast gravity perception. J Gravit Physiol. 2002 Jul;9(1):P257-60. PDF

  • Hughes-Fulford, M. (2002) Physiological effects of microgravity on osteoblast morphology and cell biology. Adv Space Biol Med. 8:129-57. PDF

  • Hughes-Fulford, M.(2002) Changes in gene expression in signal transduction in microgravity, Journal of Gravitational Physiology, P1-4. PDF

2001

  • Hughes-Fulford, M., Chen Y, Tjandrawinata RR. (2001) Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells. Carcinogenesis. 22(5):701-7. PDF

  • Chen Y, Hughes-Fulford, M. Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2. J Cancer. 1;91(1):41-5.2001. PDF

  • 2000

  • Chen Y, Hughes-Fulford, M. Prostaglandin E2 and the protein kinase A pathway mediate arachidonic acid induction of c-fos in human prostate cancer cells. Br J Cancer 2000 Jun;82(12):2000-6. PDF

  • Lewis ML and Hughes-Fulford, M., Regulation of heat shock protein message in Jurkat cells cultured under serum-starved and gravity-altered conditions. J Cell Biochem. 2000 Apr;77(1):127-134. PDF

  • Fitzgerald J, Dietz TJ and Hughes-Fulford, M. Prostaglandin E2-induced up-regulation of c-fos messenger ribonucleic acid is primarily mediated by 3',5'-cyclic adenosine monophosphate in MC3T3-E1 osteoblasts. Endocrinology. 2000 Jan;141(1):291-8. PDF

1999

  • Hughes-Fulford, M., Using cell biology in planning the Mars Mission, The Biochemist 25-9, 1999. PDF

  • Lum,D., McQuaid,K and Hughes-Fulford, M. (1999) Co-ordinate up regulation of low density lipoprotein receptor and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas Int. J of Cancer. 8:83(2): 162-166. PDF

  • Fitzgerald, J and Hughes-Fulford, M. (1999) Mechanically induced c-fos expression is mediated by cAMP in MC3T3-E1 osteoblasts FASEB J, 13: 553-557. PDF

  • Hughes-Fulford, Millie and Vicki Gilbertson. (1999) Osteoblast fibronectin mRNA, protein synthesis and matrix is not changed after long term exposure to microgravity. (1999) FASEB J 13, S121-128. PDF

  • Hughes-Fulford, Millie, Raymond Tjandrawinata, Jamie Fitzgerald, Kimberly Gasuad and Vicki Gilbertson. (1999) Effect of microgravity on osteoblast growth activation: Analysis of transcription, translation and morphology on STS-76. Biorack on Spacehab, by Brinkmann and Brillouet. ed: M. Perry European Space Agency ISBN 92-9092-484-5. PDF

1998

  • Hughes-Fulford, Millie and Vicki Vincent. (1998) Effects of microgravity on osteoblast growth. ASGSB Bulletin vol. 11(2), 51-60. PDF

1997

  • Hughes-Fulford, M., (1997) Prostaglandin regulation of gene expression and growth in normal and malignant tissues Adv. Exp Med. Biol. 400A: 269-278. PDF

  • Tjandrawinata, R.R.; Vincent, V.L. and Hughes-Fulford, M. (1997) Vibrational Force Alters mRNA. PDF

  • Hughes-Fulford, M., (1997) Growth Regulation of Gardeners Syndrome Colorectal Cancer Cells by NSAIDs Adv. Exp Med. Biol. 407: 433-441. PDF

  • Tjandrawinata, R and Hughes-Fulford, M. (1997) Upregulation of Cyclooxygenase 2 by Product, Prostaglandin E2 in prostate cancer Adv. Exp Med. Biol. 407: 163-170. PDF

  • Tjandrawinata,R., Rajvir, D and Hughes-Fulford, M. (1997) Induction of cyclooxygenase-2 mRNA by prostaglandin E2 in prostate cancer, British Journal of Cancer, 75:8: 1111-1118. PDF

  • Hughes-Fulford, M. (1997) Growth regulation and gene expression in cancer and normal cells by prostaglandins. Adv Exp Med Biol, 400A, 269-278.

1996

  • Hughes-Fulford, M. and Lewis, M. (1996) Effects of Microgravity on Osteoblast Growth Activation, Experimental Cell Research 224, 103-109. PDF

  • Leong,J, Hughes-Fulford, M., Rakhlin, Habib A Maclouf, J and Goldyne, M. (1996) Cyclooxygenases in Human and Mouse Skin and Cultured Human Keratinocytes: association of COX-2 expression with Human Keratinocyte Differentiation Exp Cell Research 224, 79-87. PDF

  • Fitzgerald, J. and Hughes-Fulford, M. (1996) Gravitational Loading of a Simulated launch alters mRNA expression in osteoblasts, Experimental Cell Research 228,168-171. PDF

  • Lewis, ML and Hughes-Fulford, M. (1996) Cellular Responses to Microgravity, Chapter 3, Textbook for the International Space Univ. ed. S. Churchill. Harvard University, p 71-105. PDF

1994

  • Hughes-Fulford, M. (1994) G1 cell cycle arrest by dmPGA1: Up-regulation of c-fos and c-myc oncogene expression without transition into S-Phase in S49 lymphomas. J Cell Biochem, 54:265-272. PDF

1993

  • Lin HS, Hughes-Fulford, M., (1993) Kumegawa M, and Snowdowne K. Cytoplasmic pH Influences Cytoplasmic Calcium in MC3T3-E1 osteoblast cells. J Bone and Miner Res. 8:725-732. PDF

  • Hughes-Fulford, M. (1993) Growth and repair of mineralized osteoblasts, Spinal Instability, Holtzman R, McCormick P, et. al. eds. Springer-Verlag, New York, 3-14. PDF

  • Hughes-Fulford, M, and Fukushima M. (1993) Control of cell cycle by metabolites of prostaglandin D2 through a non-cAMP mediated mechanism in lymphomas, Life Science Advances-Experimental and Clinical Endocrinology 12:57-64. PDF